The CTLA-4 Inhibitors Competitive Landscape report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details.
“CTLA-4 Inhibitors Competitive Landscape Insight, 2023“ report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the CTLA-4 inhibitors Market.
Some of the key takeaways from the CTLA-4 Inhibitors Competitive Landscape Report:
Companies across the globe are diligently working toward developing novel CTLA-4 inhibitors treatment therapies with a considerable amount of success over the years.
CTLA-4 inhibitors companies working in the treatment market are Molecular Templates, Shanghai Henlius Biotech, Harbour BioMed, Alpine Immune Sciences, Agenus, Xencor, Innovent Biologics, Alphamab Oncology, Bristol-Myers Squibb, Akeso Biopharma, and others, are developing therapies for the CTLA-4 inhibitors treatment
Emerging CTLA-4 inhibitors therapies in the different phases of clinical trials are- MT-8421, HLX-13, HBM4003, ALPN-202, Botensilimab, Vudalimab, IBI-310, KN046, Ipilimumab, Cadonilimab, and others are expected to have a significant impact on the CTLA-4 inhibitors market in the coming years.
In March 2023, Molecular Templates, Inc. obtained approval from the US Food and Drug Administration (FDA) after evaluating its Investigational New Drug Application (IND) to advance clinical trials for its innovative MT-8421 ETB program, which targets CTLA-4 in patients with relapsed/refractory solid tumors previously treated with checkpoint inhibitors. Preclinical findings from MT-8421 revealed that treatment depleted immune suppressive Tregs in the TME but not in the periphery, as observed in a transgenic mouse model expressing human CTLA-4 and harboring syngeneic subcutaneous tumors.
In March 2023, Agenus initiated a randomized, open-label, Phase II Trial of Nab-paclitaxel +Gemcitabine with or without Botensilimab (AGEN1181) in patients with metastatic pancreatic cancer who have progressedon prior 5FU + Leucovorin + Irinotecan + Oxaliplatin (FOLFIRINOX). This will be a prospective, multicenter, clinical trial ofbotensilimab in combination with nab-paclitaxel + gemcitabine or nab-paclitaxel + gemcitabine alone.
In February 2023, Akeso Biopharma Co., Ltd., in partnership with Chia Tai Tianqing Pharmaceutical Group Co., Ltd., has launched a clinical trial for Cadonilimab Plus Anlotinib in patients with recurrent, metastatic, or persistent cervical cancer. This trial aims to evaluate the efficacy of a novel treatment regimen comprising cadonilimab and anlotinib. Currently, the trial is actively enrolling participants and is anticipated to conclude by October 2024, with an expected enrollment of 48 participants.
In October 2022, The FDA greenlit tremelimumab (Imjudo), a CTLA-4 immune checkpoint inhibitor, for use in combination with durvalumab (Imfinzi) as a first-line immunotherapy for unresectable hepatocellular cancer (HCC). This new indication involves administering a single 300 mg priming dose of tremelimumab alongside durvalumab at a dose of 1,500 mg every 4 weeks, known as the STRIDE regimen (single tremelimumab, regular interval durvalumab).
In August 2022, Biocytogen Pharmaceuticals and TRACON Pharmaceuticals, Inc. revealed that the FDA granted approval for the Investigational New Drug (IND) application, allowing the commencement of a Phase I/II clinical trial for YH001 combined with envafolimab and doxorubicin. This study aims to evaluate the treatment’s efficacy in sarcoma patients, including those who have not undergone prior therapy.
CTLA-4 inhibitors Overview
CTLA-4 inhibitors, or cytotoxic T-lymphocyte-associated protein 4 inhibitors, are a class of immunotherapy drugs used in cancer treatment. CTLA-4 is a protein receptor found on the surface of T cells, a type of immune cell. It regulates the activity of T cells and helps prevent them from attacking healthy cells in the body. However, cancer cells can exploit this mechanism to evade the immune system.
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Emerging CTLA-4 inhibitors Drugs Under Different Phases of Clinical Development Include:
MT-8421: Molecular Templates
HLX-13: Shanghai Henlius Biotech
HBM4003: Harbour BioMed
ALPN-202: Alpine Immune Sciences
Botensilimab: Agenus
Vudalimab: Xencor
IBI-310: Innovent Biologics
KN046: Alphamab Oncology
Ipilimumab: Bristol-Myers Squibb
Cadonilimab: Akeso Biopharma
CTLA-4 inhibitors Route of Administration
CTLA-4 Inhibitors Competitive Landscape report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as
Oral
Parenteral
Intravenous
Subcutaneous
Topical
CTLA-4 inhibitors Molecule Type
CTLA-4 inhibitors Products have been categorized under various Molecule types, such as
Monoclonal Antibody
Peptides
Polymer
Small molecule
Gene therapy
CTLA-4 Inhibitors Competitive Landscape Therapeutics Assessment
CTLA-4 inhibitors Assessment by Product Type
CTLA-4 inhibitors By Stage and Product Type
CTLA-4 inhibitors Assessment by Route of Administration
CTLA-4 inhibitors By Stage and Route of Administration
CTLA-4 inhibitors Assessment by Molecule Type
CTLA-4 inhibitors by Stage and Molecule Type
DelveInsight’s CTLA-4 inhibitors Report covers around 50+ products under different phases of clinical development like
Late-stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I)
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates
Route of Administration
Further CTLA-4 inhibitors product details are provided in the report. Download the CTLA-4 Inhibitors Competitive Landscape report to learn more about the emerging CTLA-4 inhibitors therapies
Some of the key companies in the CTLA-4 inhibitors Therapeutics Market include:
Key companies developing therapies for CTLA-4 inhibitors are – Innovent Biologics, Alphamab Oncology, Agenus, Harbour BioMed, AstraZeneca, Alpine Immune Sciences, Henlix Biotech, DotBio, TrueBinding, Ocean Biomedical, Xencor, Molecular Templates, Akeso, Inc., TRACON Pharmaceuticals, Inc., Biocytogen Pharmaceuticals, and others.
CTLA-4 Inhibitors Competitive Landscape Analysis:
The CTLA-4 Inhibitors Competitive Landscape report provides insights into
The report provides detailed insights about companies that are developing therapies for the treatment of CTLA-4 inhibitors with aggregate therapies developed by each company for the same.
It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for CTLA-4 inhibitors Treatment.
CTLA-4 inhibitors key companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
CTLA-4 inhibitors Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the CTLA-4 inhibitors market.
The report is built using data and information traced from the researcher’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc.
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CTLA-4 Inhibitors Competitive Landscape Market Drivers
Rise in prevalence of Cancer, increased focus on the applications ofImmunotherapy using CTLA-4 inhibitors for oncology settings are some of the important factors that are fueling the CTLA-4 inhibitors Market.
CTLA-4 Inhibitors Competitive Landscape Market Barriers
However, side-effects associated with the checkpoint inhibitors immunotherapy, high cost associated with the Treatment and other factors are creating obstacles in the CTLA-4 inhibitors Market growth.
Scope of CTLA-4 Inhibitors Competitive Landscape Drug Insight
Coverage: Global
Key CTLA-4 inhibitors Companies: Molecular Templates, Shanghai Henlius Biotech, Harbour BioMed, Alpine Immune Sciences, Agenus, Xencor, Innovent Biologics, Alphamab Oncology, Bristol-Myers Squibb, Akeso Biopharma, and others
Key CTLA-4 inhibitors Therapies: MT-8421, HLX-13, HBM4003, ALPN-202, Botensilimab, Vudalimab, IBI-310, KN046, Ipilimumab, Cadonilimab, and others
CTLA-4 inhibitors Therapeutic Assessment: CTLA-4 inhibitors current marketed and CTLA-4 inhibitors emerging therapies
CTLA-4 inhibitors Market Dynamics: CTLA-4 inhibitors market drivers and CTLA-4 inhibitors market barriers
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Table of Contents
1. CTLA-4 inhibitors Report Introduction
2. CTLA-4 inhibitors Executive Summary
3. CTLA-4 inhibitors Overview
4. CTLA-4 inhibitors- Analytical Perspective In-depth Commercial Assessment
5. CTLA-4 Inhibitors Competitive Landscape Therapeutics
6. CTLA-4 inhibitors Late Stage Products (Phase II/III)
7. CTLA-4 inhibitors Mid Stage Products (Phase II)
8. CTLA-4 inhibitors Early Stage Products (Phase I)
9. CTLA-4 inhibitors Preclinical Stage Products
10. CTLA-4 inhibitors Therapeutics Assessment
11. CTLA-4 inhibitors Inactive Products
12. Company-University Collaborations (Licensing/Partnering) Analysis
13. CTLA-4 inhibitors Key Companies
14. CTLA-4 inhibitors Key Products
15. CTLA-4 inhibitors Unmet Needs
16 . CTLA-4 inhibitors Market Drivers and Barriers
17. CTLA-4 inhibitors Future Perspectives and Conclusion
18. CTLA-4 inhibitors Analyst Views
19. Appendix
20. About DelveInsight
About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate business growth and overcome challenges with a practical approach.
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