2018 Nobel Prize in Chemistry Awarded for Directed Evolution and Phage Display

October 09 20:30 2018
On October 3rd, the 2018 Nobel Prize in Chemistry was awarded to the field of biochemistry, in which Frances H. Arnold of US won half in recognition of her directed evolution of enzymes, and George P. Smith of US and Gregory P. Winter of UK shared the other half in recognition of their phage display technology for peptides and antibodies.

On October 3rd, the 2018 Nobel Prize in Chemistry was awarded to the field of biochemistry, in which Frances H. Arnold of US won half in recognition of her directed evolution of enzymes, and George P. Smith of US and Gregory P. Winter of UK shared the other half in recognition of their phage display technology for peptides and antibodies.

Mutation, selection, reproduction, and repeat for millions of generations are four extremely essential parts during the evolution. Directed evolution uses a similar strategy to create biomolecules for use in diverse fields spanning industrial production, medical science, and basic research, which helps achieve results much more quickly, in many cases with just a few rounds of mutagenesis and selection.

Phage display is a long-lasting laboratory platform for the large-scale study of molecules interaction, mainly based on displaying the interest protein on the surface of employing phage and then be used to interrogate the constructed libraries containing millions or even billions of displayed phages.

As one of the most successful applications, phage display technology has proved its safety and efficiency in the research and development of specific antibodies. In Creative Biolabs, a professional provider engaged in phage display field, customized library construction services are available to generate different types of phage display libraries, including but not limited to:

· Antibody library construction service

· Scaffold library construction service

· Peptide library construction service

· cDNA library construction service

World class premade human and mouse antibody libraries with great capacity & diversity are also offered, which can derive highly specific, high affinity antibodies ranging from 10 pM to 10 nM, including human scFv libraries, human Fab libraries, mouse scFv/Fab libraries, rabbit Fab libraries, chicken scFv libraries and single domain antibody libraries.

Based on the advanced phage display technology, scientists in Creative Biolabs are also specialized in the production and discovery of specific single domain antibodies. Camel, llama, alpaca or even shark as repertoire source can be immunized to develop single domain antibodies against interested targets (antigens) in terms of clients’ specific needs. Various targets are employed in immunization, including large protein molecules, membrane proteins, haptens and other challenging targets.

With years of research and development, Creative Biolabs has extensive experience in phage display platform by employing various types of phage in various project objectives. Creative Biolabs is pleased to share our cutting-edge technology and extensive expertise in single domain antibody to facilitate clients’ research and project development. High-quality services are customized by adjusting protocols to meet even the most specific requirements.

Media Contact
Company Name: Creative Biolabs
Contact Person: Bella Smith
Email: Send Email
Phone: 1-631-619-7922
Address:45-1 Ramsey Road
City: Shirley
State: New York
Country: United States
Website: https://www.creative-biolabs.com/

  Categories: